Evidence map›Paper›PMID 42532039›Full record

ArticleImmunity2026

The liver-secreted protein FGL1 restrains a subset of innate-like B cell responses via the receptor TACI.

Tina Tianjiao Su, Jianwei He, Yuge Wang, Jiaoyan Huang, Baozhu Huang, Ala Nassar, Laure Willen, Mahya Eslami, Chunxiang Wu, Meiyi Huang and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Tina Tianjiao SuDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Jianwei HeDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Yuge WangDepartment of Biostatistics, Yale University, New Haven, CT 06520, USA.
Jiaoyan HuangDepartment of Pathology, New York University, New York, NY 10016, USA.
Baozhu HuangDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Ala NassarDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Laure WillenDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.
Mahya EslamiDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland.
Chunxiang WuDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Meiyi HuangDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Jianping ZhangDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Runxia GuDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Lan JiDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Ti BadriDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Xuan YangDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA.
Hyeon Jun ShinDepartment of Medicine, Yale University, New Haven, CT 06520, USA.
Min-Jong KangDepartment of Medicine, Yale University, New Haven, CT 06520, USA.
Lokesh SharmaDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Matthew D VeselyDepartment of Dermatology, Yale University, New Haven, CT 06511, USA.
Yong XiongDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Hongyu ZhaoDepartment of Biostatistics, Yale University, New Haven, CT 06520, USA.
Pascal SchneiderDepartment of Immunobiology, University of Lausanne, Epalinges 1066, Switzerland. Electronic address: pascal.schneider@unil.ch.
Jun WangDepartment of Pathology, New York University, New York, NY 10016, USA. Electronic address: jun.wang@nyulangone.org.
Lieping ChenDepartment of Immunobiology, Yale University, New Haven, CT 06511, USA; Department of Medicine, Yale University, New Haven, CT 06520, USA; Department of Dermatology, Yale University, New Haven, CT 06511, USA. Electronic address: lieping.chen@yale.edu.

Funding

Elucidating the Role of Cancer-Associated FGL1 in Tumor Immunity and Developing FGL1-Guided Anti-LAG-3 Cancer ImmunotherapyR37CA273333 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JUN WANG · 2022 to 2026
$2.8M
NCI NIH HHS R37 CA273333
6 · The paper itself

Abstract

The liver-secreted protein fibrinogen-like protein 1 (FGL1) is a ligand of the coinhibitory receptor LAG3 on T cells; however, Fgl1

Indexed as

B-LymphocytesFibrinogenImmunity, InnateLiverTransmembrane Activator and CAML Interactor ProteinAnimalsAutoimmunityB-Cell Activating FactorHumansLupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, KnockoutTumor Necrosis Factor Ligand Superfamily Member 13B-Cell Activating FactorFibrinogenTnfrsf13b protein, mouseTransmembrane Activator and CAML Interactor ProteinTumor Necrosis Factor Ligand Superfamily Member 13APRILautoimmunityBAFFB cellBCMAFGL1inhibitoryLAG-3lupusTACI

Identifiers

PMID42532039
PMCPMC13637965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.