Evidence map›Paper›PMID 42531660›Full record

ArticleJournal of inorganic biochemistry2026

Evaluating metal complex enantiomers: Lessons from a photobiological study.

Troy T Handlovic, Ge Shi, Saba Aslani, Alisher Talgatov, Houston D Cole, John A Roque, Colin G Cameron, Daniel W Armstrong, Sherri A McFarland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Troy T HandlovicDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States.
Ge ShiDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States.
Saba AslaniDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States.
Alisher TalgatovDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States.
Houston D ColeDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States.
John A RoqueDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States.
Colin G CameronDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States. Electronic address: colin.cameron@uta.edu.
Daniel W ArmstrongDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States. Electronic address: sec4dwa@uta.edu.
Sherri A McFarlandDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX 76019-0065, United States. Electronic address: sherri.mcfarland@uta.edu.

Funding

Immunomodulating Ruthenium Metal Complexes for Melanoma PhotodynamicTherapyR01CA222227 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI GUJAR, SHASHI, MCFARLAND, SHERRI · 2018 to 2022
$2.6M
NCI NIH HHS R01 CA222227
6 · The paper itself

Abstract

Chiral coordination complexes continue to attract interest as potential therapeutic agents, yet their stereochemical properties are rarely examined with the rigor now standard in organic drug discovery. Here we investigate whether the Δ and Λ enantiomers of the highly potent Ru(II) oligothienyl photosensitizer ML19G01 exhibit intrinsic differences in photobiological activity. Five independently synthesized batches of rac-ML19G01 were separated by direct chiral chromatography on a functionalized cyclofructan-6 (CF6-RN) stationary phase using both LC and sub/supercritical fluid chromatography. Enantiomeric excess was established by analytical chiral HPLC, absolute configuration was assigned by vibrational circular dichroism (VCD)/DFT comparison, and removal of trifluoroacetic acid (TFA), triethylamine (TEA), and counterion impurities was verified by

Indexed as

Coordination ComplexesPhotosensitizing AgentsRutheniumCell Line, TumorChromatography, High Pressure LiquidCircular DichroismHumansStereoisomerismCoordination ComplexesPhotosensitizing AgentsRutheniumAbsolute configurationCoordination complexesEnantiomersPhotobiological activityVibrational circular dichroism

Identifiers

PMID42531660
PMCPMC13679649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.