Evidence map›Paper›PMID 42531551›Full record

ReviewGlobal spine journal2026

Does Duration of Symptoms in Metastatic Spine Disease Affect Recovery and Outcomes? A Systematic Review and Meta-Analysis.

Harsh Jain, Nick De Oliveira, Advith Sarikonda, Ori Barzilai, Nicolas Dea, Alessandro Gasbarrini, C Rory Goodwin, Cordula Netzer, Jeremy Reynolds, Laurence D Rhines and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Global spine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Harsh JainDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-9396-3989
Nick De OliveiraVanderbilt University School of Medicine, Nashville, TN, USA.
Advith SarikondaDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Ori BarzilaiDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nicolas DeaCombined Neurosurgical and Orthopedic Spine Program, Department of Orthopedics Surgery, University of British Columbia, Vancouver, BC, Canada.
Alessandro GasbarriniDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
C Rory GoodwinDepartment of Neurosurgery, Spine Division, Duke University, Durham, NC, USA.ORCID 0000-0002-6540-2751
Cordula NetzerDepartment of Spine Surgery, University Hospital of Basel, Basel, Switzerland.ORCID 0000-0001-7381-373X
Jeremy ReynoldsDepartment of Spinal Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Laurence D RhinesDepartment of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, University of Texas, Houston, TX, USA.ORCID 0000-0002-8474-1521
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Jorrit-Jan VerlaanDepartment of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Daniel M SciubbaDepartment of Neurosurgery, Northwell Health, New Hyde Park, NY, USA.
Ilya LauferDepartment of Neurosurgery, New York University Langone Health, New York, NY, USA.
Scott L ZuckermanDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-2951-2942

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Neuro-immune modulation of pain in health and diseaseR01DE031053 · NIDCR · DUKE UNIVERSITY · PI Christopher Ryan Donnelly · 2022 to 2026
$3.3M
NCI NIH HHS P30 CA008748NIDCR NIH HHS R01 DE031053
6 · The paper itself

Abstract

Study DesignSystematic review and meta-analysis.ObjectivesWe sought to evaluate the association between pre-treatment symptom duration and outcomes in patients undergoing radiotherapy (RT)/surgery for metastatic epidural spinal cord compression (MESCC).MethodsA systematic review included publications evaluating the association between pre-treatment symptom duration and outcomes after RT/surgery in adults with MESCC. Primary exposure was pre-treatment symptom duration. Outcomes were motor-recovery, ambulation, survival and local control. Pooled-effect-estimates were calculated.Results Of 4639 studies, 37 met the inclusion criteria (26-RT,11-surgery).

Indexed as

motor deficitsradiotherapyspine tumorsurvivalsymptom duration

Identifiers

PMID42531551
PMCPMC13423946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.