ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2026
The impact of age and exercise training on endothelial-mediated mechanisms of vasodilation during passive leg movement in males.
Brady E Hanson, Nicholas A Carlini, Jesse C Craig, Jay R Hydren, Angela V Bisconti, Andrew C Kithas, Katherine L Shields, Soung Hun Park, Jayson R Gifford, Catherine L Jarrett and 9 more
Abstract read
In one paragraphArticle in American journal of physiology. Regulatory, integrative and comparative physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
19 authors.
Brady E HansonDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0002-4495-3028 Nicholas A CarliniDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.
Jesse C CraigDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-5959-4139 Jay R HydrenDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-9385-8898 Angela V BiscontiDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0003-0156-2593 Andrew C KithasDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.
Katherine L ShieldsDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-5399-7332 Soung Hun ParkDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0002-1423-0929 Jayson R GiffordDepartment of Exercise Sciences, Brigham Young University, Provo, Utah, United States.ORCID 0000-0002-6034-306X Catherine L JarrettDepartment of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington, United States.
Oh Sung KwonDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut, United States.ORCID 0000-0002-9929-6774 Ashley D NelsonDepartment of Internal Medicine, Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, Utah, United States.
David E MorganDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, United States.
Jacob E JessopDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, United States.
Amber D BledsoeDepartment of Anesthesiology, University of Utah, Salt Lake City, Utah, United States.
Gregory J StoddardDivision of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.
Russell S RichardsonDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0003-0233-5923 Ryan M BroxtermanDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0002-7388-2214 Joel D TrinityDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-8271-6536 Funding
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during DisuseR01HL142603 · NHLBI · UNIVERSITY OF UTAH · PI TRINITY, JOEL DOUGLAS · 2019 to 2023
$2.9MCSRD VA IK2 CX002114HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142603NHLBI NIH HHS R01 HL142603RRD VA I01 RX003810U.S. Department of Veterans Affairs (VA) Advanced Fellowship in GeriatricsU.S. Department of Veterans Affairs (VA) E1572-PU.S. Department of Veterans Affairs (VA) E1697-RU.S. Department of Veterans Affairs (VA) E2323-RU.S. Department of Veterans Affairs (VA) E3207-RU.S. Department of Veterans Affairs (VA) E6910-RU.S. Department of Veterans Affairs (VA) E9275-LU.S. Department of Veterans Affairs (VA) I01RX0003810U.S. Department of Veterans Affairs (VA) IK2CX002114
6 · The paper itselfAbstract
Passive leg movement (PLM) offers a robust method for assessing vascular function; however, the interactions among age, endothelial-mediated vasodilatory mechanisms, and exercise training-induced PLM modulation remain poorly understood. To address these gaps, the vasodilatory responses to PLM, quantified as leg vascular conductance (LVC) dynamics, were measured in younger (
Indexed as
AgingEndothelium, VascularExerciseLegVasodilationAgedAge FactorsHumansMaleMovementNitric OxideNitric Oxide SynthaseProstaglandinsRegional Blood FlowNitric OxideNitric Oxide SynthaseProstaglandinsendothelial functionexercise trainingnitric oxidepassive leg movementvasodilator mechanisms
Identifiers
PMID42531290
PMCPMC13528187
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