ArticleChemistry & biodiversity2026
Phlomomelanosides A-E, Five New Iridoid Glycosides From the Whole Plant of Phlomoides melanantha and Their Biological Activities.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Phlomoides melanantha, a perennial herb belonging to the genus Phlomoides within the Lamiaceae family, has not been previously studied for its chemical constituents. In this research, a phytochemical investigation on the whole plant of P. melanantha led to the isolation of eleven glycosides, including five novel iridoid glycosides named phlomomelanosides A-E (1-5) and six known analogues (6-11). The structures and relative configurations of these isolated compounds were determined using high-resolution mass spectrometry and detailed 1D and 2D nuclear magnetic resonance techniques. Additionally, the absolute configurations of 1, 4, and 5 were determined by comparing experimental and calculated electronic circular dichroism spectra. The antioxidant properties of all isolated compounds were evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Compound 4 exhibited moderate scavenging activity, with an IC
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