ArticleSTAR protocols2026
Protocol to stress human primary pancreatic islets with diabetogenic factors for subsequent single-cell RNA sequencing.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Type 1 diabetes (T1D) is an autoimmune disease that destroys insulin-secreting pancreatic β cells. Using human islets is instrumental to understanding the initiation and progression of T1D. Here, we present a protocol for treating cadaveric primary human islets with inflammatory, immune, and viral stressors. We detail Coxsackievirus B3 expansion, primary islet cell culture, and treatment with diabetogenic stressors, followed by procedures for single-cell RNA sequencing analysis. For complete execution details, please refer to Maestas et al.
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