ArticleThe Journal of international medical research2026
Causal relationship between aging-related biomarkers and osteoporosis: A bidirectional two-sample Mendelian randomization study.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
ObjectiveThe potential causal role of molecular biomarkers of biological aging in osteoporosis remains uncertain. This study aimed to evaluate whether genetically predicted levels of aging-related traits are causally associated with the risk of osteoporosis.MethodsIn this study, we selected eight exposures: telomere length, mitochondrial DNA copy number, insulin-like growth factor 1 levels, DNA methylation PhenoAge acceleration, leucine, isoleucine, valine, and Dickkopf-related protein 1. A bidirectional two-sample Mendelian randomization analysis was conducted among the European population. The inverse-variance weighted method served as the primary analysis, complemented by Mendelian randomization-Egger, weighted median, mode-based methods, Cochran's Q test, the Mendelian randomization-Egger intercept, and leave-one-out analysis to assess robustness, heterogeneity, and pleiotropy.ResultsThe inverse-variance weighted analysis showed nominal associations (p
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