Evidence map›Paper›PMID 42530830›Full record

ArticleJournal of endocrinological investigation2026

Subtle diastolic dysfunction in children with idiopathic subclinical hypothyroidism: effect of two years of l-thyroxine treatment.

M Arcopinto, M Salerno, R Di Mase, A Salzano, F R Rotondo, S Vasaturo, A Cittadini, D Capalbo

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Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

M ArcopintoDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
M SalernoPediatric Endocrinology Unit, Department of Mother and Child, University Hospital Federico II of Naples, Endo-ERN Center for Rare Endocrine Conditions, Naples, Italy.
R Di MasePediatric Endocrinology Unit, Department of Mother and Child, University Hospital Federico II of Naples, Endo-ERN Center for Rare Endocrine Conditions, Naples, Italy.
A SalzanoDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
F R RotondoPediatric Endocrinology Unit, Department of Translational Medical Sciences, University Hospital Federico II of Naples, Naples, Italy.
S VasaturoPediatric Endocrinology Unit, Department of Translational Medical Sciences, University Hospital Federico II of Naples, Naples, Italy.
A CittadiniDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
D CapalboPediatric Endocrinology Unit, Department of Mother and Child, University Hospital Federico II of Naples, Endo-ERN Center for Rare Endocrine Conditions, Naples, Italy. donatella.capalbo@unina.it.ORCID http://orcid.org/0000-0003-3312-8628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeData about clinical implications of subclinical hypothyroidism (SH) in children are scanty, and the management of this condition is still challenging particularly for mild forms (TSH levels ranging between 4.5 and 10 mU/L). Aim of this study is to compare left ventricular (LV) geometry and function in SH children and matched euthyroid controls, and to evaluate the cardiac effects of L-thyroxine (L-T

methodsThirty-six children (19 females), aged 8.3 ± 0.7 years, with persistent and idiopathic SH were enrolled in the study. Thirty-six euthyroid children comparable for sex, age and body mass index were enrolled as controls. Baseline echocardiography and biochemical assessment was performed in all subjects. Thereafter, SH children started L-T

resultsThe LV cavity size was comparable between SH and controls, at baseline, and increased similarly over time. LV systolic function was normal at baseline in both groups and remained comparable at end-study. With regard to diastolic function, SH children showed a significant prolongation of isovolumic relaxation time (IVRT) compared with controls (92.95 ± 3.74 vs 76.13 ± 2.75 msec, p = 0.0006), with normal E/A and E/E' ratios in both populations, consistent with subclinical, mild diastolic dysfunction. After L-T

conclusionLong-lasting mild SH in children is associated with subtle abnormality of LV relaxation which improves with L-T

Indexed as

ChildrenDiastolic functionHeartLevothyroxineSubclinical hypothyroidism

Identifiers

PMID42530830

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