Evidence map›Paper›PMID 42530775›Full record

ArticleJournal of hematopathology2026

Leukemic presentation of ALK-positive anaplastic large cell lymphoma in an adult patient with hemophagocytic lymphohistiocytosis.

Mark Oliver, Jenny Byrd, Eduard Matkovic

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark OliverSchool of Medicine and Public Health, Department of Pathology & Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Jenny ByrdSchool of Medicine and Public Health, Department of Pathology & Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Eduard MatkovicSchool of Medicine and Public Health, Department of Pathology & Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA. matkovic@wisc.edu.ORCID https://orcid.org/0000-0003-1492-5170

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic ALK + anaplastic large cell lymphoma (ALCL) is a CD30-positive T cell neoplasm that commonly affects lymph nodes with frequent involvement of extranodal sites. A leukemic phase with peripheral blood involvement is extremely rare, and therefore, recognition of this uncommon phenomenon is crucial to avoid misdiagnosis and delayed treatment. We report a case of a previously healthy adult patient who presented with peripheralizing ALK-positive ALCL accompanied by hemophagocytic lymphohistiocytosis (HLH). Comprehensive ancillary studies were essential for establishing the diagnosis and determining blood involvement.

Indexed as

Lymphohistiocytosis, HemophagocyticLymphoma, Large-Cell, AnaplasticReceptor Protein-Tyrosine KinasesAdultAnaplastic Lymphoma KinaseHumansMaleALK protein, humanAnaplastic Lymphoma KinaseReceptor Protein-Tyrosine KinasesALK-positiveAnaplastic large cell lymphomaFlow cytometryHemophagocytic lymphohistiocytosisLeukemic phasePeripheral blood involvement

Identifiers

PMID42530775
PMCPMC13424219

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.