ReviewAnnals of biomedical engineering2026
Metamaterial-Assisted Miniaturized Antennas for Targeted Microwave Hyperthermia: From Deep Tissue Focus to Energy Efficiency.
Review in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Microwave hyperthermia is a promising non-invasive tumor therapy, yet traditional energy-delivery antennas suffer from critical bottlenecks: bulkiness, shallow tissue penetration, uneven specific absorption rate distribution (SAR), and low energy efficiency. Metamaterials with artificially tailorable electromagnetic properties provide novel solutions to these challenges. This review focuses on metamaterial-assisted miniaturized antennas for targeted microwave hyperthermia, systematically elaborating on the electromagnetic hurdles in deep tissue heating, metamaterial-enabled mechanisms such as near-field control, SAR shaping and energy optimization, and two core systems: implantable and wearable. It also analyzes current technical bottlenecks such as complex manufacturing, inadequate SAR control, and immature feedback mechanisms, along with future trends including AI-driven design, reconfigurable metamaterials and millimeter-wave integration. Overall, this review aims to clarify how metamaterial-assisted antenna design can alleviate the trade-off between miniaturization and energy loss, improve treatment precision and safety, and promote the development of adaptive and clinically translatable microwave hyperthermia systems for solid tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.