Lacticaseibacillus paracasei Jlus66 ameliorates hyperuricemia by inhibiting xanthine oxidase activity, modulating uric acid transporter proteins and the gut microbiota.

Can Wang, Ling Zhu, Xue Shen, Xiaowei Xiao, Tiehua Zhang, Haiqing Ye

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Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Can WangCollege of Food Science and Engineering, Jilin University, NO.5333 Xi'an Road, Changchun, 130062, Jilin province, China.

Ling ZhuCollege of Food Science and Engineering, Jilin University, NO.5333 Xi'an Road, Changchun, 130062, Jilin province, China.

Xue ShenCollege of Food Science and Engineering, Jilin University, NO.5333 Xi'an Road, Changchun, 130062, Jilin province, China.

Xiaowei XiaoCollege of Food Science and Engineering, Jilin University, NO.5333 Xi'an Road, Changchun, 130062, Jilin province, China.

Tiehua ZhangCollege of Food Science and Engineering, Jilin University, NO.5333 Xi'an Road, Changchun, 130062, Jilin province, China.

Haiqing YeCollege of Food Science and Engineering, Jilin University, NO.5333 Xi'an Road, Changchun, 130062, Jilin province, China. yehq@jlu.edu.cn.

Funding

The Department of Science and Technology of Jilin Province 20250601047RCThe National Natural Science Foundation of China 32372451

6 · The paper itself

Abstract

A novel strain of Lacticaseibacillus paracasei Jlus66 was isolated from a traditional fermented dairy product known as "Nai Geda", and its role in hyperuricemia remains unclear. We constructed a mouse model using potassium oxonate (OXO) and a high-purine diet to examine the impacts of Jlus66 supplementation on hyperuricemia in vivo. The results revealed that Lacticaseibacillus paracasei Jlus66 intervention substantially lowered blood uric acid (UA) concentrations through suppressing xanthine oxidase (XOD) activity in the liver to reduce UA synthesis and modulating UA transport to enhance its renal excretion. Furthermore, Lacticaseibacillus paracasei Jlus66 supplementation increased short-chain fatty acids (SCFAs) in cecal samples, which might account for the reduced secretion of serum pro-inflammatory cytokines interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). Lacticaseibacillus paracasei Jlus66 enhanced intestinal barrier function through upregulating tight junction proteins and reinstating gut microbiota homeostasis. In conclusion, Lacticaseibacillus paracasei Jlus66 may be a potential probiotic for the management of hyperuricemia through modulating gut microbiota, promoting UA excretion, and inhibiting UA synthesis.

Indexed as

Gastrointestinal MicrobiomeHyperuricemiaLacticaseibacillus paracaseiOrganic Anion TransportersProbioticsUric AcidXanthine OxidaseAnimalsCytokinesDisease Models, AnimalFatty Acids, VolatileIntestinal Barrier FunctionLiverMaleMiceMice, Inbred C57BLCytokinesFatty Acids, VolatileOrganic Anion TransportersOxonic Acidpotassium oxonateTumor Necrosis Factor-alphaUric AcidXanthine OxidaseFermented dairy productsGut-liver-kidney axisGut microbiotaHyperuricemiaProbiotic

Identifiers

PMID42530645

DOI10.1007/s00394-023-03291-w

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.