ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
Intramuscular fat infiltration is associated with higher vertebral void space burden and lower volumetric bone mineral density in older adults.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
purposeEctopic fat infiltration is increasingly recognized as an important determinant of musculoskeletal health, but its relationship with localized vertebral trabecular deterioration remains unclear. This study aimed to investigate the associations of regional adipose tissue distribution, particularly intramuscular fat infiltration, with vertebral void space burden and volumetric bone mineral density (vBMD) using quantitative computed tomography (QCT).
methodsThis cross-sectional study included 327 postmenopausal women and men aged ≥ 50 years who underwent QCT. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), intermuscular adipose tissue (IMAT), and intramuscular fat fraction (IMFF) were quantified. Vertebral void space burden was assessed by void space volume (VS) and void space volume ratio (VS/TV), alongside vBMD. Multivariable linear regression, restricted cubic spline, subgroup, and sensitivity analyses were performed.
resultsHigher IMFF and IMAT were significantly associated with greater vertebral void space burden. Each 10-percentage-point increase in IMFF was associated with 257.2% higher VS and 251.8% higher VS/TV; these associations remained significant after additional adjustment for vBMD, indicating partial independence from average trabecular density (VS: 90.5%; VS/TV: 88.2%; all P < 0.001). Each 1-SD increase in IMAT was also associated with higher VS and VS/TV, independent of vBMD. Both IMFF and IMAT were inversely associated with vBMD.
conclusionsIntramuscular fat infiltration was independently associated with greater vertebral void space burden and lower vBMD, suggesting that ectopic muscle fat may provide complementary imaging information on localized vertebral structural deterioration beyond conventional density-based measures. Intramuscular fat infiltration was associated with greater vertebral void space burden and lower volumetric bone mineral density on QCT. Ectopic muscle fat may provide complementary imaging information on localized vertebral trabecular deterioration beyond average bone density alone.
Indexed as
Identifiers
42530584What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.