Evidence map›Paper›PMID 42530187›Full record

ArticleJACC. Case reports2026

This ECG Does Not Fit: Rethinking Left Ventricular Hypertrophy.

Carlotta Perini Schweiger, Giuseppe Allocca, Giorgia Gugelmo, Livia Lenzini, Alberto Cipriani, Martina Perazzolo Marra, Domenico Corrado, Nicola Vitturi, Gianni Carraro, Laura De Michieli

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlotta Perini SchweigerDepartment of Cardiac-thoracic-vascular sciences and Public health, University of Padua, Padua, Italy.
Giuseppe AlloccaDepartment of Cardiology, S Maria dei Battuti Hospital, Conegliano, Italy.
Giorgia GugelmoDivision of Metabolic Diseases, Department of Medicine, University of Padova-Padova University Hospital, Padua, Italy.
Livia LenziniDepartment of Medicine-DIMED, University Hospital, Padua, Italy.
Alberto CiprianiDepartment of Cardiac-thoracic-vascular sciences and Public health, University of Padua, Padua, Italy.
Martina Perazzolo MarraDepartment of Cardiac-thoracic-vascular sciences and Public health, University of Padua, Padua, Italy.
Domenico CorradoDepartment of Cardiac-thoracic-vascular sciences and Public health, University of Padua, Padua, Italy.
Nicola VitturiDivision of Metabolic Diseases, Department of Medicine, University of Padova-Padova University Hospital, Padua, Italy.
Gianni CarraroNephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova-Padova University Hospital, Padua, Italy.
Laura De MichieliDepartment of Cardiac-thoracic-vascular sciences and Public health, University of Padua, Padua, Italy. Electronic address: laura.demichieli@unipd.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnderson-Fabry disease (AFD) is a rare cause of left ventricular hypertrophy (LVH) that can be challenging to diagnose, particularly when comorbidities are present. CASE SUMMARY: We report a 70-year-old man with controlled hypertension, diabetes mellitus, chronic kidney disease, prior percutaneous coronary intervention on the left anterior descending artery, evaluated for progressive LVH and electrocardiogram (ECG) changes during follow-up. ECG showed an atypical pattern with right bundle branch block. Cardiac magnetic resonance then demonstrated reduced native T1 values. Genetic testing identified the p.N215S (p.Asn215Ser) GLA mutation, confirming late-onset AFD. Disease-specific management was subsequently initiated. DISCUSSION: Late-onset AFD is frequently underdiagnosed, particularly in older patients with multiple cardiovascular comorbidities. Careful ECG analysis may provide key diagnostic clues and prompt advanced imaging and genetic testing. TAKE-HOME MESSAGES: AFD should be considered in older patients with unexplained LVH. Careful evaluation of ECG abnormalities may be sufficient to trigger targeted, second-level, diagnostic tests.

Indexed as

cardiac magnetic resonancecardiomyopathyelectrocardiogram

Identifiers

PMID42530187
PMCPMC13420691

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.