Evidence map›Paper›PMID 42530085›Full record

ArticleOncoimmunology2026

Cancer associated fibroblast-T cell crosstalk promotes purinergic synthesis in non-small cell lung cancer (NSCLC).

Lilian Koppensteiner, Charles Lochenie, Richard A O'Connor, Layla Mathieson, Liam Neilson, Ahsan R Akram

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lilian KoppensteinerCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Charles LochenieCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Richard A O'ConnorCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Layla MathiesonCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Liam NeilsonCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Ahsan R AkramCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4605-1682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most abundant stromal cells of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs), inhibit the cytotoxic T cell response in solid tumors. CD39 and CD73 together deplete extracellular ATP in the TME to produce adenosine, which can promote tumor immune evasion. We aimed to investigate the role of CAF-T-cell crosstalk in the adenosine pathway in NSCLC. CD4

Indexed as

AdenosineCancer-Associated FibroblastsCarcinoma, Non-Small-Cell LungCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesLung Neoplasms5'-NucleotidaseAdenosine MonophosphateAntigens, CDApyraseCell CommunicationCoculture TechniquesGPI-Linked ProteinsHumansSignal TransductionTumor Microenvironment5'-NucleotidaseAdenosineAdenosine MonophosphateAntigens, CDApyraseCD39 antigenGPI-Linked ProteinsNT5E protein, humanadenosineCancer-associated fibroblastsNSCLCTILstumor microenvironment

Identifiers

PMID42530085
PMCPMC13432865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.