Evidence map›Paper›PMID 42530066›Full record

ArticleCancer biology & medicine2026

FDX1 expression promotes DSF/Cu-induced cuproptosis in gastric cancer cells.

Qirong Li, Yi Guo, Jiahuan Yuan, Qiang Feng, Hengzong Zhou, Ming Hao, Boqiang Tao, Liqun Sun, Chao Lin, Jianfeng Mu and 2 more

Abstract read
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In one paragraph

Article in Cancer biology & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qirong LiLaboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China.
Yi GuoThe Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130000, China.
Jiahuan YuanLaboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China.
Qiang FengLaboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China.
Hengzong ZhouLaboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China.
Ming HaoDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun 130000, China.
Boqiang TaoDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun 130000, China.
Liqun SunOutpatient Department of Pediatrics, Children's Medical Center, The First Hospital of Jilin University, Changchun 130000, China.
Chao LinAnimal Science Department, School of Grain Engineering and Nutritional Science, Jilin Business and Technology College, Changchun 130000, China.
Jianfeng MuDepartment of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130000, China.
Gongliang GuoDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130000, China.ORCID 0009-0000-7163-6581
Dongxu WangLaboratory Animal Center, College of Animal Science, Jilin University, Changchun 130000, China.ORCID 0000-0003-0464-1596

Funding

Jilin Province Science and Technology Development Program YDZJ202201ZYTS069Jilin University Young Teachers and Students Cross-disciplinary Training 2023-JCXK-08Wenzhou Science & Technology Bureau Basic Public Welfare Research Program Y20240006
6 · The paper itself

Abstract

objectiveGastric cancer (GC) is a prevalent malignant tumor that warrants the development of drugs and therapeutic targets. Cuproptosis has emerged as a promising mechanism by which to inhibit tumors because copper homeostasis disorders frequently occur in various malignancies. The combination of disulfiram (DSF) and copper ions (DSF/Cu) has been shown to have significant antitumor effects. This study utilized DSF/Cu to investigate the mechanism underlying cuproptosis in GC cells.

methodsGC cells were treated with DSF/Cu and protein sequencing was performed to screen for differentially expressed genes. The mechanism by which overexpressed

resultsDSF/Cu had a good therapeutic effect on promoting cuproptosis in GC cells. Protein sequencing revealed

conclusionsThis study showed that DSF/Cu promoted cuproptosis and the expression of

Indexed as

CopperCuproptosisDisulfiramStomach NeoplasmsAnimalsCell Line, TumorExosomesGene Expression Regulation, NeoplasticHumansMiceXenograft Model Antitumor AssaysCopperDisulfiramCuproptosisDSF/Cugastric cancerNK cell exosomes

Identifiers

PMID42530066
PMCPMC13617952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.