Evidence map›Paper›PMID 42529886›Full record

ArticleJournal of Zhejiang University. Science. B2026

Machine learning-driven evaluation of protein kinase D3 as a co-diagnostic biomarker in hepatocellular carcinoma.

Jing Li, Yifan Zhao, Yicheng Ma, Bei Xie, Li Huang, Haitang Yang, Xingyuan Ma, Haohua Deng, Shuaiyang Wang, Chanjuan Sun and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jing LiDepartment of Clinical Laboratory Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
Yifan ZhaoSchool of Information Science and Engineering, Lanzhou University, Lanzhou 730000, China.
Yicheng MaDepartment of Clinical Laboratory Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
Bei XieDepartment of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
Li HuangDepartment of Pediatric Nephrology, Lanzhou University Second Hospital, Lanzhou 730030, China.
Haitang YangDepartment of Clinical Laboratory Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
Xingyuan MaSchool of Second Clinical Medical, Lanzhou University, Lanzhou 730030, China.
Haohua DengSchool of Second Clinical Medical, Lanzhou University, Lanzhou 730030, China.
Shuaiyang WangSchool of Second Clinical Medical, Lanzhou University, Lanzhou 730030, China.
Chanjuan SunSchool of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China.
Pengfei CaoSchool of Information Science and Engineering, Lanzhou University, Lanzhou 730000, China. lilinj@lzu.edu.cn, caopf@lzu.edu.cn.
Linjing LiDepartment of Clinical Laboratory Center, Lanzhou University Second Hospital, Lanzhou 730030, China. lilinj@lzu.edu.cn.

Funding

the Chengguan District Talent Innovation and Entrepreneurship Project in Lanzhou City 2024-rc-2the Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital CY2024-ZD-01the General Projects of Gansu Provincial Joint Research Fund 23JRRA1503the Key Incubation Project Funds of the Second Hospital and Clinical Medical School, Lanzhou University 2025-22-zdfy-001 and 2025-25-zdfy-002the Key Research and Development Program of Gansu Province 25YFFA052the Lanzhou Science and Technology Plan Project 2025-2-88the Lanzhou Talent Innovation and Entrepreneurship Project 2023RC28the National Natural Science Foundation of China 82573290, 82272405, 82060531 and 81602622the Natural Science Foundation of Gansu Province 23JRRA0984 and 24JRRA431
6 · The paper itself

Abstract

To elucidate the diagnostic value and clinical relevance of protein kinase D3 (PRKD3) in hepatocellular carcinoma (HCC), we analyzed data retrieved from The Cancer Genome Atlas (TCGA) database, which revealed high expression of

Indexed as

Biomarkers, TumorCarcinoma, HepatocellularLiver NeoplasmsMachine LearningProtein Kinase CAgedFemaleHumansMaleMiddle AgedRandom ForestROC CurveBiomarkers, TumorProtein Kinase CCombined diagnosisHepatocellular carcinoma (HCC)Machine learningProtein kinase D3 (PRKD3)

Identifiers

PMID42529886
PMCPMC13420521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.