ReviewAnnals of medicine2026
Beyond the role in motor function, entopeduncular nucleus, a critical neural hub in psychiatric disorders and sleep regulation.
Review in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe entopeduncular nucleus (EP) is a major output nucleus of the basal ganglia and plays a critical role in integrating motor, emotional, and behavioral processes. Although traditionally linked to motor control, accumulating evidence indicates that the EP is deeply involved in psychiatric disorders, sleep regulation, addiction, and mood-related behaviors. As the rodent homolog of the human internal Globus pallidus (GP) the EP represents a key translational structure bridging preclinical and clinical neuroscience.
methodsThis narrative review was conducted following established narrative review methodology. Relevant literature was identified through a structured search of major biomedical databases. Peer-reviewed experimental and clinical studies investigating EP anatomy, connectivity, neurotransmitter systems, and functional roles were included. The review synthesizes findings from mouse and rat models employing optogenetic and chemogenetic manipulation, electrophysiological recording, neuroanatomical tracing, molecular approaches, and behavioral assays, alongside human neuroimaging, lesion, and deep brain stimulation studies.
resultsEvidence from rodent models demonstrates that the EP functions as a convergence hub integrating GABAergic, glutamatergic, dopaminergic, serotonergic, and endocannabinoid signaling. EP projections to the lateral habenula regulate aversive processing, addiction-related behaviors, and mood states. Cell-type-specific mouse studies identify entopeduncular circuits implicated in anxiety regulation. Dysregulation of EP circuits is implicated in depression, anxiety, and Parkinsonian motor dysfunction. Clinical and preclinical neuromodulation studies further support the therapeutic relevance of targeting EP circuits.
conclusionThe EP is a multifunctional neural hub extending beyond motor control. Integrating evidence from rodent and human studies highlights its importance in psychiatric and sleep disorders and supports its potential as a translational therapeutic target.
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