ReviewFrontiers in nutrition2026
The role of diet in the pathogenesis and management of premature ovarian insufficiency.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Premature ovarian insufficiency (POI) is characterized by an early decline in ovarian function before the age of 40 and is highly associated with infertility and long-term health issues. Increasing evidence suggests that dietary factors and nutritional status may influence ovarian aging and susceptibility to POI. Dietary patterns with high antioxidant and anti-inflammatory potential, such as the Mediterranean and plant-based diets, have been associated with more favorable indicators of ovarian reserve, whereas Western-style dietary patterns may accelerate ovarian functional decline. Nutrients, including vitamin D, omega-3 polyunsaturated fatty acids, and antioxidant compounds, may affect ovarian function through multiple biological processes, including modulation of oxidative stress, inflammation, mitochondrial activity, endocrine and metabolic homeostasis, epigenetic regulation, and the gut microbiota-ovarian axis. However, most available evidence is gained from observational studies and animal models. So far, the causal relationships have not yet been firmly established. Improvement in overall diet quality and appropriate supplementation of key nutrients may represent safe and potentially supportive strategies for the prevention and management of POI. Nevertheless, well-designed longitudinal studies and randomized controlled trials are required to clarify the effects of diet on ovary and to define optimal dietary intervention strategies for preserving ovarian health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.