ArticleFrontiers in medicine2026
dNLR, NLR, and NMLR as differential markers for assessing severity and sepsis in emphysematous pyelonephritis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aims to evaluate the association between blood count-derived inflammatory markers and the severity of radiographic disease, as well as the presence of sepsis in patients with Emphysematous pyelonephritis. Methods: This retrospective cohort study included 47 adult patients diagnosed with EPN. Anatomical severity was assessed using Huang's grading system based on admission CT scans. Sepsis diagnosis followed the Sepsis-3.0 criteria. CBC-derived indices were calculated from initial admission blood test results. Intergroup comparisons, effect size analysis, receiver operating characteristic curves, and correlation analyses were performed. Results: The derived neutrophil-to-lymphocyte ratio (dNLR) had a statistically significant association with Huang's CT classification ( Conclusion: dNLR, NLR, and NMLR are readily obtainable CBC-derived indicators that show distinct clinical associations in EPN. dNLR correlates with anatomical disease severity, while NLR and NMLR are superior indicators for identifying concomitant sepsis. These inexpensive markers offer practical, complementary tools for acute-phase risk stratification, aiding in the timely recognition of severe disease and systemic complications.
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