O‑Glycosylation Shapes the Proteolytic Landscape of the Native Tear Peptidome.

Vincent Chang, Ryan J Chen, Isaac Lian, Keira E Mahoney, Stacy A Malaker

Abstract read

In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Site-specific O-glycans influence lacritin structure and multimerization in tears.Protein science : a publication of the Protein Society · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vincent ChangDepartment of Chemistry, Yale University, 225 Prospect St, New Haven, Connecticut 06511, United States.

Ryan J ChenDepartment of Chemistry, Yale University, 225 Prospect St, New Haven, Connecticut 06511, United States.

Isaac LianDepartment of Chemistry, Yale University, 225 Prospect St, New Haven, Connecticut 06511, United States.

Keira E MahoneyDepartment of Chemistry, Yale University, 225 Prospect St, New Haven, Connecticut 06511, United States.ORCID https://orcid.org/0000-0003-4561-9838

Stacy A MalakerDepartment of Chemistry, Yale University, 225 Prospect St, New Haven, Connecticut 06511, United States.ORCID https://orcid.org/0000-0003-2382-5067

Funding

Toward understanding the role of altered glycosylation in cancerR35GM147039 · NIGMS · YALE UNIVERSITY · PI Stacy Alyse Malaker · 2022 to 2026

$2.0M

NIGMS NIH HHS R35 GM147039

6 · The paper itself

Abstract

The endogenous tear peptidome plays essential roles in maintaining ocular homeostasis by stimulating immune response and participating in antimicrobial activity. The biological function of these native peptides is governed by their biochemical properties, including peptide length, charge, and hydrophobicity. Accordingly, the production of native peptides within the tear film is tightly regulated through a complex interplay between circulating proteases and the proteolytic susceptibility of the protein substrate. Though glycosylation has been shown to regulate the proteolysis of specific proteins

Indexed as

cleavageglycopeptidomeglycoproteomicsmass spectrometrypeptidomeproteolysistear fluid

Identifiers

PMID42529429

DOI10.1021/jacsau.6c00834

PMCPMC13417242

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.