ArticleChemical & biomedical imaging2026
Reconfiguration of the Microtubule Network and Dynamics in Hypoxic Cancer Cells.
Article in Chemical & biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Cancer cells within solid tumors adapt to hypoxic microenvironments caused by vasculature disruption. Oxygen deprivation induces changes in cell signaling and metabolism, leading to increased resistance to treatment and elevated metastasis. The microtubule network plays a crucial role in cell signaling and migration; however, few studies have investigated its time-dependent dynamics in live hypoxic cancer cells. Here, we applied advanced optical microscopy to study microtubule dynamics and their relationships with local mitochondrial activities and cell migration in hypoxia. Our results show that hypoxia exposure does not significantly alter the speed of microtubule polymerization but induces the formation of microtubule-rich protrusions. This protrusion formation largely requires glycolytic activity and the availability of nutrients. Furthermore, mitochondria relocation into these protrusions was found, along with localized expression of nucleoside-diphosphate kinase. Using real-time precision opto-control technology, we selectively disrupted mitochondrial function within the protrusions, which led to reduced local microtubule polymerization, highlighting the role of site-specific mitochondrial activity in supporting local microtubule dynamics. Moreover, hypoxia-induced microtubule-rich protrusions can be correlated with cancer cell migration. Together, these findings reveal how hypoxia reorganizes microtubules and mitochondria in cancer cells, how localized mitochondrial activity regulates microtubule polymerization, and how these changes influence cancer cell migration under hypoxia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.