Evidence map›Paper›PMID 42529400›Full record

ArticleJACS Au2026

Early- and Late-Stage Chemoenzymatic Functionalization of Steroid-Inspired Compounds.

Frederik Simonsen Bro, Thomas Whitmarsh-Everiss, Hogan P Bryce-Rogers, Laura Depta, Mariusz Kubus, Hans Renata, Luca Laraia

Abstract read
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Frederik Simonsen BroDepartment of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark.ORCID https://orcid.org/0000-0002-7149-9246
Thomas Whitmarsh-EverissDepartment of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark.ORCID https://orcid.org/0000-0002-9958-7379
Hogan P Bryce-RogersDepartment of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark.ORCID https://orcid.org/0000-0002-3186-9601
Laura DeptaDepartment of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark.
Mariusz KubusDepartment of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark.
Hans RenataDepartment of Chemistry, BioScience Research Collaborative, Rice University, Houston, Texas 77005, United States.
Luca LaraiaDepartment of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark.ORCID https://orcid.org/0000-0001-6692-3412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective C-H functionalization of small molecule leads is a powerful approach for efficient chemical space exploration and medicinal chemistry optimization. Here, we report a screening strategy for early- and late-stage chemoenzymatic oxidation of steroid-inspired compounds using a panel of P450

Indexed as

biocatalysischemoenzymatic synthesisC–H functionalizationlate-stage functionalizationsteroidsstructure-activity relationship

Identifiers

PMID42529400
PMCPMC13417283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.