Total Synthesis and Biological Evaluation of Exiguamines.

Seungjoo Noh, Jisook Park, Yeehwan Kim, Venkat R Krishnamurthy, Chang-Ki Min, Eun Young Choi, Chulbom Lee

Abstract read

In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seungjoo NohDepartment of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.

Jisook ParkDepartment of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.

Yeehwan KimDepartment of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.

Venkat R KrishnamurthyDepartment of Chemistry, Princeton University, Princeton, New Jersey 08540, United States of America.ORCID https://orcid.org/0000-0002-9015-7436

Chang-Ki MinDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

Eun Young ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Chulbom LeeDepartment of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.ORCID https://orcid.org/0000-0001-9566-5977

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A concise and divergent total synthesis of the marine indoloquinone natural product exiguamine has been accomplished. The synthetic strategy relies on a hydantoin linchpin approach that unites the tryptamine- and dopamine-derived subunits, setting the stage for efficient construction of the core framework. A Claisen rearrangement forges the critical C-C bond, and a subsequent oxidative cyclization cascade assembles the hexacylic skeleton, including the pyran and indolinium rings. Beyond the natural products exiguamines A and B, this route provided access to their constitutional isomers

Indexed as

enzyme inhibitorsheterocyclesnatural productssigmatropic rearrangementtotal synthesis

Identifiers

PMID42529393

DOI10.1021/jacsau.6c00734

PMCPMC13417199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.