ArticleFrontiers in medicine2026
Detection of latent tuberculosis infection in patients prior to and following heart transplantation.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Early identification of latent tuberculosis infection (LTBI) is essential for preventing active tuberculosis in heart transplant candidates and recipients, particularly in the context of immunosuppressive therapy. Aim: To assess and compare the prevalence of LTBI in patients awaiting heart transplantation and in heart transplant recipients using modern immunodiagnostic methods. Methods: The prospective study was conducted between 2025 and 2026 and included patients listed for heart transplantation at the Almazov National Medical Research Centre. Patients were divided into two main groups according to whether heart transplantation was performed was conducted to evaluate immunodiagnostic: I group - patients prior to heart transplantation ( Results: LTBI prevalence was significantly higher in heart transplant recipients (53.6%) compared with controls (5.8%; χ Conclusion: Heart transplant recipients demonstrate the highest prevalence of LTBI, followed by patients awaiting transplantation, both markedly exceeding that observed in healthy individuals. These findings indicate an elevated risk of active tuberculosis in this population and support the importance of routine LTBI screening and preventive therapy.
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