ReviewJACS Au2026
From Blueprint to Breakthrough: How Far Can We Fold DNA Origami for Nano-Enabled Technologies?
Review in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA origami has emerged as a groundbreaking approach in nanotechnology, offering unparalleled precision, programmability, and structural versatility at the molecular scale. Originally conceived as a method to fold DNA into arbitrary 2D and 3D shapes, DNA origami has rapidly evolved into a multifunctional platform, enabling the construction of dynamic, responsive, and addressable nanostructures. As we stand at the intersection of biology, physics, and engineering, this perspective explores how far we can truly "fold" DNA origami, not just structurally but functionally, toward the realization of advanced nanoenabled technologies. We examine the foundational design principles that have propelled DNA origami from static nanoshapes to reconfigurable architectures capable of precise molecular actuation. By integrating functional elements such as quantum dots, metallic nanoparticles, and biomolecules, DNA origami has unlocked novel possibilities in optoelectronics, ranging from plasmonic nanodevices to photonic nanostructures, and in biomedicine, where it serves as a vehicle for targeted drug delivery, biosensing, and immunomodulation. Despite these achievements, several grand challenges remain, including issues of scalability, structural stability under operational conditions, and integration with other nanomaterials and systems. This perspective reflects on the current state of the field and identifies opportunities for future innovation, particularly through convergence with artificial intelligence, machine-learning-guided design, and hybrid materials science. Ultimately, we posit that DNA origami is no longer just a tool for nanoscale construction but a foundational technology poised to redefine the frontiers of optoelectronics, diagnostics, and therapeutics. As we continue to push the boundaries of what can be folded, this article invites the scientific community to rethink the potential of DNA origami from blueprint to breakthrough in shaping the future of nanoenabled applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.