ArticleChemical science2026
NMR crystallography of the high-pressure form of a multi-component active pharmaceutical ingredient.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pressure and mechanical forces during pharmaceutical manufacturing can induce solid-phase transformations of active pharmaceutical ingredients (APIs), posing risks to product quality. Here, we report the structural characterization of a metastable high-pressure polymorph of the multi-component GDC-0022 tosylate salt formed under applied pressure of 250 MPa. The crystal structure of the high-pressure polymorph is determined with a combination of
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