Evidence map›Paper›PMID 42529236›Full record

ArticleFrontiers in radiology2026

Diagnostic value of quantitative MR spectroscopy metabolite ratios for Canavan disease.

Majid Reza Tahsini, Marzena Wylezinska-Arridge, Mohammad Zare, Sasan Saket, Mohammad Aidin Farahvash, Mahdis Morovvati, Elham Rahimian, Sotirios Bisdas

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Article in Frontiers in radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Majid Reza TahsiniHaghighat medical imaging research center, Haghighat medical imaging center, Tehran, Iran.
Marzena Wylezinska-ArridgeLysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Trust, London, United Kingdom.
Mohammad ZareDepartment of Statistics, Faculty of Mathematical Sciences, Alzahra University, Tehran, Iran.
Sasan SaketDepartment of Pediatric Neurology, School of Medicine, Imam Hossein & Mofid Children's Hospitals, Tehran, Iran.
Mohammad Aidin FarahvashRoozbeh Hospital, Faculty of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran.
Mahdis MorovvatiHaghighat medical imaging research center, Haghighat medical imaging center, Tehran, Iran.
Elham Rahimian *Haghighat medical imaging research center, Haghighat medical imaging center, Tehran, Iran.
Sotirios Bisdas *Department of Translational Neuroscience and Stroke, Queen Square Institute of Neurology, University College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Canavan disease (CD) is a leukodystrophy marked by deficiency in the aspartoacylase enzyme and accumulation of N-acetyl aspartate (NAA) in the white matter. MRI and MRS are crucial diagnostic tools for CD. MRS shows a distinctive, significant elevation of the NAA peak, which is typically not quantified and thus not objectively assessed as a diagnostic criterion. This study aimed to establish quantitative cutoff values for the elevated NAA peak on proton MR spectroscopy ( Methods: A cross-sectional retrospective diagnostic study involving 18 confirmed CD cases and 10 healthy individuals was conducted to assess metabolic profiles and determine a diagnostic cutoff for NAA in CD. 1H MRS (TE: 135 ms) was utilized, and data were post-processed using specialized software to quantify the ratios of the three primary metabolites: NAA, Cho, and Cr. Results: The analysis of the CD cases demonstrated substantial elevation in NAA levels compared to the standard control group with the NAA/Cr and NAA/Cho ratios significantly increased in CD patients compared to controls ( Conclusion: This study represents one of the larger single-center cohorts evaluating quantitative MRS metabolite ratios in Canavan disease and proposes preliminary diagnostic thresholds for improved diagnostic objectivity.

Indexed as

Canavan diseasehypomyelinating disordersleukodystrophiesmagnetic resonance spectroscopyN-acetyl-aspartate (NAA)

Identifiers

PMID42529236
PMCPMC13416435

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