ArticleFrontiers in cardiovascular medicine2026
Does sex shape the biological footprint of balloon-in-basket pulsed field ablation-guided pulmonary vein isolation? A biomarker analysis.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The balloon-in-basket pulsed field ablation (BiB-PFA) system is a novel modality that achieves myocardial-selective ablation with minimal collateral tissue injury. Sex-related differences in biomarker responses following BiB-PFA-guided pulmonary vein isolation (PVI) for atrial fibrillation (AF) remain unclear. Objective: We aimed to investigate sex-based differences in peri-procedural biomarker responses and procedure-related complications among patients undergoing PVI alone using the BiB-PFA system. Methods: We retrospectively analyzed patients undergoing initial PVI with the BiB-PFA system between January 2024 and March 2026. Peri-procedural inflammatory, myocardial injury, hemolysis, and renal biomarkers were assessed pre-ablation and on the first post-procedural day. Sex-based differences in biomarker changes (Δ = post - pre) and procedural safety outcomes were compared. Results: A total of 50 patients were included (50% female). Baseline characteristics and procedural parameters were comparable between groups. Δ values in inflammatory markers (Δwhite blood cell count: Conclusions: No statistically significant sex-related differences were detected in peri-procedural biomarker responses or observed procedural complications following BiB-PFA-guided PVI.
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