ArticleFrontiers in cardiovascular medicine2026
Thyroid autoimmunity and spontaneous cervicocranial artery dissection: an exploratory segment-specific case-control study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Immune-mediated mechanisms are thought to contribute to the local vascular inflammation associated with spontaneous cervicocranial arterial dissection (SCCAD). However, evidence linking thyroid autoimmunity to SCCAD remains conflicting. Furthermore, the potential correlation between thyroid autoimmunity and the anatomical distribution of dissections has not been evaluated. Methods: This retrospective, hospital-based case-control study was conducted from June 2021 to May 2025, enrolling 164 patients with SCCAD and 164 healthy controls. Multivariate logistic regression analyses, and patient-level sensitivity analyses were employed to examine the impact of thyroid autoantibodies on SCCAD and their anatomical distributions. Additionally, propensity score matching, stratified analyses and interaction tests were performed to assess the robustness of the association between thyroid autoimmunity and SCCAD. Results: Multivariate analyses showed that, compared with healthy controls, SCCAD had significantly higher rates of thyroid autoimmunity positivity (OR 6.715; 95% CI: 1.589-28.377; Discussion: In conclusion, thyroid autoimmunity positivity and elevated TPOAb were independently associated with SCCAD, and TPOAb demonstrated a previously unrecognized segment-specific association with vertebral artery dissections-positive at V4 and inverse at V3.
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