ArticleFrontiers in immunology2026
Dual inhibition of CSF-1R and IDO modulates the fibrotic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma.
Lara C Avsharian, Suvithanandhini Loganathan, Nancy D Ebelt, Rebecca E Ruggiero-Ruff, Sheyla Salcido, Skye E Inal, Meera G Nair, Edwin R Manuel
Abstract read
In one paragraphArticle in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
8 authors.
Lara C Avsharian *Department of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Suvithanandhini Loganathan *Department of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Nancy D EbeltDepartment of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Rebecca E Ruggiero-RuffDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, United States.
Sheyla SalcidoDepartment of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Skye E InalDepartment of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Meera G NairDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, United States.
Edwin R ManuelDepartment of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3MProject 2U54CA285116 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ERNEST MARTINEZ, RUI SU · 2023 to 2026
$6.8MDevelopment of Microbial-Based Therapies to Suppress Macropinocytosis in Kras-Driven CancersR01CA272732 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Edwin Ramos Manuel · 2022 to 2026
$2.0MMicrobial- based targeting of major extracellular matrix components for improved therapy of pancreatic cancerR01CA266472 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI MANUEL, EDWIN · 2022 to 2025
$1.8MModulating Intratumoral Immune Composition to Enhance ImmunotherapyR21CA293969 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI MANUEL, EDWIN · 2024 to 2024
$458kNCI NIH HHS P30 CA033572NCI NIH HHS R01 CA266472NCI NIH HHS R01 CA272732NCI NIH HHS R21 CA293969NCI NIH HHS U54 CA285116
6 · The paper itselfAbstract
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive forms of solid tumors, is characterized by extensive fibrosis and an immunosuppressive tumor microenvironment (TME) that limits therapeutic efficacy. Tumor-associated macrophages (TAMs), especially those with a pro-tumor, M2-like phenotype, contribute to immune evasion and fibrosis via TGF-β signaling and CSF-1R-mediated recruitment. Using two orthotopic PDAC models that differ in stromal composition and baseline CSF-1R expression (KPC4662.5 and Pan02), we evaluated whether therapeutic response to macrophage-targeting strategies is context dependent. Consistent with established studies, highly fibrotic KPC4662.5 tumors exhibited elevated Arg1, α-SMA, TGF-β1, and CSF-1R expression relative to Pan02 tumors. In high fibrotic, CSF1R
Indexed as
Carcinoma, Pancreatic DuctalIndoleamine-Pyrrole 2,3,-DioxygenasePancreatic NeoplasmsReceptor, Macrophage Colony-Stimulating FactorTumor MicroenvironmentAnimalsCell Line, TumorFemaleFibrosisHumansMiceTumor-Associated MacrophagesIndoleamine-Pyrrole 2,3,-DioxygenaseReceptor, Macrophage Colony-Stimulating Factorcombination therapydrug delivery platformimmuno oncologyimmunotherapyPDAC - pancreatic ductal adenocarcinomatumor microenvironment
Identifiers
PMID42529118
PMCPMC13416583
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