ArticleHealth science reports2026
Exploring the Paradoxical Association Between Chest CT Pulmonary Involvement and Olfactory Dysfunction in COVID-19 Patients: A Prospective Cross-Sectional Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background and Aims: Olfactory dysfunction (OD) is common in COVID-19, yet its relationship with pulmonary involvement remains inconsistent. We evaluated the association between CT-based lung involvement and OD in laboratory-confirmed COVID-19. Methods: In a prospective cross-sectional study (Yasuj University of Medical Sciences hospitals; December 26, 2021-May 22, 2022), OD was assessed using the CCCRC protocol and pulmonary involvement was categorized using a CT lung involvement score. Associations were examined using chi-square testing (categorical) and ANOVA where appropriate (α = 0.05). Results: Among 120 patients (60 male/60 female; mean age 43.17 ± 14.76 years), 71 (59.2%) had hyposmia, and none had complete anosmia. CT pulmonary involvement was present in 40 (33.3%). OD category was significantly associated with the pulmonary involvement category (chi-square test; Conclusion: OD was frequent and showed a statistically significant association with CT-based pulmonary involvement; however, OD severity alone should not be used as a stand-alone surrogate for pulmonary involvement. Larger multicenter studies are needed to clarify the observed pattern.
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