ArticleFrontiers in pediatrics2026
Influencing factors of peripheral blood indicators on 30-day mortality risk in children with hemophagocytic lymphohistiocytosis based on weighted quantile sum regression: a single-center retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the joint effect of peripheral blood parameters on the 30-day mortality risk in children with hemophagocytic lymphohistiocytosis (HLH) using weighted quantile sum (WQS) regression, and to elucidate the clinical weights of each feature. Methods: A retrospective cohort design was adopted. A total of 133 pediatric HLH patients diagnosed at the Children's Medical Center of the Affiliated Hospital of Guangdong Medical University between January 1, 2015, and December 30, 2024, were included. The patients were divided into a non-survival group ( Results: Univariate analysis indicated that red blood cell distribution width (RDW), mean corpuscular hemoglobin (MCH), hematocrit (HCT), and hemoglobin (Hb) were significantly associated with early mortality risk. The negative-direction WQS regression model revealed that the overall improvement of peripheral blood parameters had a significant joint protective effect against 30-day mortality risk ( Conclusion: The analytical strategy incorporating the WQS regression model effectively mitigates collinearity interference among clinical variables. Abnormalities in peripheral blood parameters, primarily driven by HCT and MCH, serve as a exploratory composite indicator for predicting early fatal outcomes in pediatric HLH, offering a potential early warning signal for critical triage in the early stages of the disease.
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