ArticleFrontiers in medicine2026
Fibrinogen and catheter advancement difficulty: unveiling the key predictors of early
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Peripherally inserted central catheter (PICC) is widely used for medium-to-long-term venous access, but early puncture site bleeding within 48 h remains a common complication, potentially leading to increased morbidity and healthcare costs. Identifying independent risk factors is crucial for developing targeted prevention strategies. Methods: In this single-center, retrospective study, a consecutive cohort of patients who successfully underwent PICC insertion between March 2024 and March 2025 was enrolled. The study population was divided based on the criterion of Results: A total of 375 patients were included in the final analysis, with an Conclusion: Lower fibrinogen level and catheter advancement difficulty are independent risk factors for early PICC-related bleeding, while a tumor diagnosis appears protective. These findings highlight the importance of pre-procedural coagulation assessment and meticulous catheter placement.
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