ArticleFrontiers in oncology2026
Circular RNA circEVI5 functions as a miR-433 sponge to promote renal cell carcinoma progression via GBP2-mediated oncogenic signaling.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Renal cell carcinoma (RCC) is a fatal urological malignancy with limited therapeutic options and poor prognosis. Emerging evidence has shown that a number of circular RNAs (circRNAs) exert crucial effects on carcinogenesis. Nevertheless, the biological role of circEVI5 in RCC remains poorly clarified. This study aimed to elucidate the clinical significance, biological functions, and molecular mechanisms of circEVI5 in RCC pathogenesis. Methods: The expression profile of circEVI5 was first screened based on GEO and TCGA-KIRC datasets, and further verified in RCC cell lines (A498, 786-O, ACHN, CAKI-1, OSRC-2) and normal renal tubular epithelial HK-2 cells using qRT-PCR. Functional assays (CCK-8, Transwell) and a subcutaneous xenograft model were employed to assess circEVI5's role in proliferation, migration, and invasion. RNA pull-down, RIP, and dual-luciferase reporter assays were conducted to validate interactions among circEVI5, miR-433, and GBP2. Clinical correlations were further analyzed based on TCGA datasets and immunohistochemical staining results. Results: CircEVI5 was significantly upregulated in RCC tissues (median FC=6.619; P<0.05) and cell lines, correlating with advanced tumor stage (median FC=7.691; P<0.05) and poor survival (P=0.035). Knockdown of circEVI5 via small interfering RNA inhibited cell viability, migration, and invasion Discussion: Our findings establish circEVI5 as a novel oncogenic driver that facilitates RCC progression through the miR-433/GBP2 regulatory axis. The circEVI5/miR-433/GBP2 network represents a potential therapeutic target, and circEVI5 may serve as a prognostic biomarker for RCC patients. This study highlights the critical role of circRNA-mediated miRNA sponging in RCC pathogenesis and provides a framework for developing RNA-based therapies.
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