ReviewFrontiers in immunology2026
Distribution and function of human long-lasting T cells in aging and non-small cell lung cancer.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
T lymphocytes, essential components of the adaptive immune system, orchestrate pathogen-specific responses and long-term immunological memory through heterogeneous subsets with distinct functional properties and spatial distributions. This comprehensive review delineates the origin, distribution, and functional specialization of long-lasting T cell subsets-naive T cells (Tn), stem cell-like memory T cells (Tscm), central memory T cells (Tcm), effector memory T cells (Tem), and tissue-resident memory T cells (Trm)-across physiological and pathological contexts, with a particular focus on aging and non-small cell lung cancer (NSCLC). We further dissect the complex intertwined mechanisms underlying immunosenescence and NSCLC pathogenesis. Elucidating how aging remodels T cell maintenance, tissue tropism and metabolic adaptation provides a conceptual framework for developing targeted therapeutic interventions against NSCLC.
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