ArticleFrontiers in public health2026
Independent and synergistic effects of sedentary lifestyle and obstructive sleep apnea on hyperuricemia: a nationwide cross-sectional study in Korea.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Hyperuricemia, a precursor to gout and a risk factor for various cardiometabolic and renal disorders, is influenced by a complex interplay of lifestyle, physiological, and environmental factors. This study aimed to investigate the independent and combined effects of a sedentary lifestyle and obstructive sleep apnea (OSA) on hyperuricemia. Methods: We analyzed data from 14,808 participants aged 40-80 years in the Korea National Health and Nutrition Examination Survey (2019-2022). Sedentary lifestyle was defined based on daily sedentary time, categorized as ≤6 or >6 h/day. OSA risk was assessed using the STOP-Bang questionnaire (Snoring, Tiredness, Observed apnea, blood Pressure, Body mass index, Age, Neck circumference, Gender), classifying participants into high- and low-risk groups. Hyperuricemia was defined as serum uric acid levels ≥7.0 mg/dL in males and ≥6.0 mg/dL in females. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) were calculated using multiple logistic regression, and interaction effects were evaluated through relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (SI). Results: Sedentary time [AOR = 1.16 (95% CI: 1.04-1.29)] was independently associated with increased hyperuricemia risk. High OSA risk was associated with hyperuricemia in the partially adjusted model [AOR = 1.94 (95% CI: 1.71-2.19)], although this association was attenuated and no longer statistically significant after further adjustment for variables incorporated into the STOP-Bang questionnaire [AOR = 1.12 (95% CI: 0.98-1.28)]. A significant synergistic interaction was evident when both coexisted [RERI = 0.14 (95% CI: 0.08-0.19), AP = 0.17 (95% CI: 0.09-0.25), SI = 1.17 (95% CI: 1.01-1.37)]. Discussion: These findings highlight the need for integrated screening and management strategies targeting sedentary lifestyles and OSA to mitigate hyperuricemia and its associated health burdens in at-risk populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.