Evidence map›Paper›PMID 42528672›Full record

ArticleFrontiers in cellular and infection microbiology2026

Efficacy of traditional Chinese Medicine-based biological extracts in the treatment of oral lichen planus.

Xiangyu Chen, Lekai Wang, Chaojun Xu, Caiyan Gu, Caohui He, Lu Sun, Xinhai Yu

Abstract readNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiangyu ChenHunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, Hunan, China.
Lekai WangDepartment of Stomatology, YiYang Central Hospital, YiYang, Hunan, China.
Chaojun XuDepartment of Stomatology, YiYang Central Hospital, YiYang, Hunan, China.
Caiyan GuDepartment of Stomatology, YiYang Central Hospital, YiYang, Hunan, China.
Caohui HeDepartment of Stomatology, YiYang Central Hospital, YiYang, Hunan, China.
Lu SunDepartment of Stomatology, YiYang Central Hospital, YiYang, Hunan, China.
Xinhai YuHunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Our network meta-analysis aimed to evaluate the efficacy of traditional Chinese Medicine(TCM)-based biological extracts treatment for patients with oral lichen planus (OLP). Methods: A systematic search of PubMed, Embase and Web of Science was conducted to identify randomized controlled trials evaluating the efficacy of TCM-based biological extracts in treating OLP. A network meta-analysis was then performed on the eligible trials, and the TCM-based biological extracts were ranked based on their effectiveness in OLP treatment using the Surface Under the Cumulative Ranking (SUCRA) scores. Results: In total, 22 articles were included in the meta-analysis. Direct comparisons showed that TCM-based biological extracts treatment significantly reduced visual analog scale (VAS) scores in OLP patients with an Conclusions: This study provides strong evidence for the efficacy of TCM-based biological extracts in the treatment of OLP through network meta-analysis, and in particular, TCM-based biological extracts such as echinacea and honey demonstrated significant advantages in relieving pain and improving clinical symptoms.

Indexed as

Biological ProductsDrugs, Chinese HerbalLichen Planus, OralMedicine, Chinese TraditionalHumansRandomized Controlled Trials as TopicTreatment OutcomeBiological ProductsDrugs, Chinese Herbalbiological extractsimmunologyoral lichen planuspharmacologytraditional Chinese medicine

Identifiers

PMID42528672
PMCPMC13414812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.