ArticleFrontiers in physiology2026
DCR-like restrictive resuscitation is associated with enhanced oxygen metabolism, coagulation recovery, and reduced inflammation in severe chest trauma and shock.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The optimal fluid resuscitation strategy for severe chest trauma with hemorrhagic shock remains debated, with limited evidence incorporating comprehensive physiological endpoints. This study compared a restrictive (damage-control resuscitation-like) strategy versus conventional crystalloid-predominant resuscitation in this high-risk population. Methods: This single-center retrospective cohort study used propensity score matching (1:1) to balance age, sex, Injury Severity Score, and shock severity, yielding 200 matched patients (100 per group). Outcomes included 28-day survival, major complications (ARDS, DIC, MODS), ventilator- and ICU-free days, and serial (0-72 h) assessments of oxygen metabolism (SvO Results: The restrictive group received significantly less total fluid (1985 ± 325 vs. 2846 ± 492 mL, Conclusion: In this observational, single-center study, a DCR-like restrictive strategy was associated with superior physiological trajectories and improved short-term clinical outcomes compared with conventional resuscitation. These hypothesis-generating findings do not establish causality and underscore the need for prospective randomized controlled trials before any practice change.
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