Evidence map›Paper›PMID 42528559›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Human GPR174 deficiency drives polyclonal lymphoproliferative disease via defects in T cell function.

Yun-Han Huang, Kathya Arana, Suzanna Rachimi, Hanson Tam, Jarmila Stremenova Spegarova, Karin R Engelhardt, Helen Griffin, Molly Mee, Maurizio Miano, Federica Raggi and 24 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Yun-Han HuangHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-3431-2163
Kathya AranaImmunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0006-0812-726X
Suzanna RachimiImmunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7294-8683
Hanson TamHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-5772-0680
Jarmila Stremenova SpegarovaNewcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.ORCID 0000-0002-0710-9266
Karin R EngelhardtNewcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.ORCID 0000-0001-8513-9682
Helen GriffinNewcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.ORCID 0000-0002-5288-3322
Molly MeeNewcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.
Maurizio MianoHematology Unit, IRCCS Instituto Giannina Gaslini, Genoa, Italy.ORCID 0000-0002-9816-1704
Federica RaggiHematology Unit, IRCCS Instituto Giannina Gaslini, Genoa, Italy.ORCID 0000-0002-6089-1752
Alice GrossiAggregation Area of Research Laboratories, IRCCS Istituto Giannina Gaslini, Genoa, Italy.ORCID 0000-0002-4570-3485
Marta RusminiClinical Bioinformatics, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0002-3109-413X
Isabella CeccheriniAggregation Area of Research Laboratories, IRCCS Istituto Giannina Gaslini, Genoa, Italy.ORCID 0000-0001-8732-1955
Gianluca Dell'OrsoHematology Unit, IRCCS Instituto Giannina Gaslini, Genoa, Italy.ORCID 0000-0002-6555-7219
Jacopo FerroPathology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.ORCID 0000-0002-1670-178X
Maria Carla GiarratanaHematology Unit, IRCCS Instituto Giannina Gaslini, Genoa, Italy.
Vinodh PillaiDivision of Hematopathology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-7126-6226
Siddharth BankaDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0002-8527-2210
Tomaz GarcezImmunology Department, Manchester University NHS Foundation Trust, Manchester, UK.ORCID 0000-0002-8106-0480
Tracy A BriggsManchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Health Innovation Manchester, Manchester, UK.ORCID 0000-0001-5208-2691
Fethi MellouliPediatric Immunohematology Service, Bone Marrow Transplant Center, Tunis, Tunisia.
Sandra von HardenbergDepartment of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-3680-7450
Rita BeierPaediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-7568-8749
Bernd AuberDepartment of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0003-1880-291X
Ulrich BaumannHannover Medical School, Pediatric Immunology, Hannover, Germany.ORCID 0000-0002-0162-0266
Hasan TawamieInstitute of Human Genetics, Essen University Hospital, Essen, Germany (Now at First Genomics, Dubai, United Arab Emirates).
Edward BehrensDepartment of Pediatrics, Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-4603-7963
Derek A OldridgeCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-2177-5633
Emylette Cruz CabreraDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Ying XuHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.ORCID 0009-0002-8618-1561
Shinyi OuyangHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.ORCID 0009-0007-1907-8325
Sophie HambletonNewcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.ORCID 0000-0001-7954-3267
Neil RombergDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-1881-5318
Jason G CysterHoward Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-4735-9745

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVID A. MANKOFF · 1985 to 2026
$222.3M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Una T O'Doherty · 1999 to 2026
$78.6M
Medical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5M
B LYMPHOCYTE MIGRATION AND HOMEOSTASISR01AI040098 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason G Cyster · 1997 to 2026
$7.0M
Academic Rheumatology and Clinical ImmunologyT32AR079068 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jinoos Yazdany, JULIE ZIKHERMAN · 2021 to 2026
$2.5M
The molecular circuits controlling human T follicular regulatory cell developmentR01AI179680 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI NEIL DAVID ROMBERG · 2025 to 2026
$1.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
NCI NIH HHS P30 CA016520NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI040098NIAID NIH HHS R01 AI179680NIAMS NIH HHS T32 AR079068NIGMS NIH HHS T32 GM141323NIH HHS S10 OD028511Wellcome Trust
6 · The paper itself

Abstract

The X-linked G-protein coupled receptor GPR174 is highly expressed in T and B lymphocytes and has immunoregulatory roles in mice, but its function in humans is unknown. We describe a cohort of six individuals who have function-disrupting variants in

Identifiers

PMID42528559
PMCPMC13409280

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.