Evidence map›Paper›PMID 42528553›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Concerns, Priorities, and Pathways: Healthcare Provider Perspectives on Implementing Tuberculosis Preventive Treatment for People with HIV in Indonesia and the Philippines.

Prashant Kulkarni, Laura Steiner, Alieen Gianan-Gascon, Candice Eula Lamigo, Bianca Joyce Sornillo, Ruth Anne Hechanova-Cruz, Anna Maureen Dungca-Lorilla, Aljira Fitya Hapsari, Retnosari Hardaningsih, Mira Yulianti and 7 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Prashant KulkarniJohns Hopkins Centre for Infectious Diseases in India (CIDI), Pune, India.ORCID 0000-0002-6066-586X
Laura SteinerJohns Hopkins University, School of Medicine, Baltimore, USA.
Alieen Gianan-GasconResearch Institute for Tropical Medicine - Department of Health, Muntinlupa City, Philippines.ORCID 0009-0003-3769-4747
Candice Eula LamigoResearch Institute for Tropical Medicine - Department of Health, Muntinlupa City, Philippines.
Bianca Joyce SornilloResearch Institute for Tropical Medicine - Department of Health, Muntinlupa City, Philippines.ORCID 0009-0001-0023-139X
Ruth Anne Hechanova-CruzResearch Institute for Tropical Medicine - Department of Health, Muntinlupa City, Philippines.ORCID 0009-0009-3140-8862
Anna Maureen Dungca-LorillaResearch Institute for Tropical Medicine - Department of Health, Muntinlupa City, Philippines.
Aljira Fitya HapsariUniversitas Indonesia, Jakarta, Indonesia.
Retnosari HardaningsihCiptoMangunkusumo General Hospital, Jakarta, Indonesia.
Mira YuliantiCiptoMangunkusumo General Hospital, Jakarta, Indonesia.
Anshari Saifuddin HasibuanCiptoMangunkusumo General Hospital, Jakarta, Indonesia.ORCID 0000-0003-4331-2381
Evy YunihastutiCiptoMangunkusumo General Hospital, Jakarta, Indonesia.
Priyanka RaichurJohns Hopkins Centre for Infectious Diseases in India (CIDI), Pune, India.
Rossana DitangcoResearch Institute for Tropical Medicine - Department of Health, Muntinlupa City, Philippines.
Jonathan E GolubJohns Hopkins University, School of Medicine, Baltimore, USA.
Christopher J HoffmannJohns Hopkins University, School of Medicine, Baltimore, USA.
Mark Donald C ReñosaResearch Institute for Tropical Medicine - Department of Health, Muntinlupa City, Philippines.ORCID 0000-0002-7414-7174

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
NIAID NIH HHS U01 AI069907
6 · The paper itself

Abstract

Background: Tuberculosis preventive therapy (TPT) is a cornerstone intervention for reducing TB incidence among people living with HIV, yet its integration into routine care remains inconsistent in high-burden settings. While policy frameworks are well established, less is known about how frontline healthcare workers (HCWs) operationalize TPT within constraint health systems. Thisstudy explores healthcare workers' (HCWs) perspectives on TPT implementation in Indonesia and the Philippines using normalization process theory (NPT), to understand how TPT is (or fails to be) embedded in everyday clinical practice. Methods: Weconducted ten focus group discussions and four in-depth interviews with HCWs across major TB/HIV treatment centers in Manila, Philippines and Jakarta, Indonesiabetween June to December 2023. Data were analyzed using reflexive thematic analysis, followed by interpretative mappingontofour NPT constructs: coherence, cognitive participation, collective action and reflexive monitoring. Results: TPT implementation was characterized by a persistent gap between policy intent and routine practice. Under Conclusions: TPT implementation is not limited by awareness alone but by the absence of routinized systems that support consistent practice. Strengthening implementation requires shifting from individual-dependent delivery toward system-enabled integration, through standardized protocols, distributed workforce engagement, embedded monitoring mechanisms, and uninterrupted drug supply systems. Interventions that align with everyday clinical workflows and reinforce collective responsibility across cadres are critical to closing policy and practice gap.

Indexed as

Healthcare providersHIVPeople living with HIVTPT implementationTuberculosis

Identifiers

PMID42528553
PMCPMC13409217

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.