Evidence map›Paper›PMID 42528420›Full record

ArticleMolecular reproduction and development2026

Epididymosome-Supplemented Extender Induces Changes in Morpho-Functional Traits and microRNA Levels of Post-Thaw Sperm and Improves Embryo Developmental Potential.

Laura Gabrielli Haupenthal, Maria Alice de Almeida, Cibele Maria Prado, Amanda Nespolo Silva, Gabriela Melendes Schneider, Paola Maria da Silva Rosa, Flávio Vieira Meirelles, Juliano Coelho da Silveira, Felipe Perecin, Maíra Bianchi Rodrigues Alves

Abstract read
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In one paragraph

Article in Molecular reproduction and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura Gabrielli HaupenthalDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Maria Alice de AlmeidaDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Cibele Maria PradoDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Amanda Nespolo SilvaDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Gabriela Melendes SchneiderDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Paola Maria da Silva RosaDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Flávio Vieira MeirellesDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Juliano Coelho da SilveiraDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Felipe PerecinDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Maíra Bianchi Rodrigues AlvesDepartment of Pathology, Theriogenology and One Healthy, School of Agricultural and Veterinary Sciences, São Paulo State University, Jaboticabal, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-9480-6608

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 143539/2021-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 305286/2024-2Conselho Nacional de Desenvolvimento Científico e Tecnológico 305977/2024-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/21829-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/23685-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/06645-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/08759-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/09886-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/01433-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/01505-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/13164-6
6 · The paper itself

Abstract

While molecular signature contributes to sperm quality and fertility potential, sperm may lost key molecules during cryopreservation. Since sperm cells are transcriptionally inert and rely on interactions with epididymosomes (epEVs) to acquire molecules, herein, we investigated the effects of the addition of epEVs to the cryopreservation extender on post-thaw sperm quality and fertility potential. Epididymal sperm were obtained from six bulls (n = 6) and a pool of epEVs was formed from the epididymal fluid of 15 bulls. After, a total of 30 × 10

Indexed as

CryopreservationCryoprotective AgentsEmbryonic DevelopmentEpididymisMicroRNAsSemen PreservationSpermatozoaAnimalsCattleFemaleMaleSperm MotilityCryoprotective AgentsMicroRNAsepididymisextracellular vesiclesin vitro fertilizationmiRNAspaternal effect

Identifiers

PMID42528420
PMCPMC13420828

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.