Evidence map›Paper›PMID 42528113›Full record

ArticleAdvanced healthcare materials2026

Dual-Locked Glutathione-Activatable Nanoassemblies With Cascade Energy Transfer for Amplified Photodynamic Immunotherapy.

Xuan Zhang, Bin Dong, Shan Su, Xinxin Li, Wenting Guo, Zhiyi Wang, Baodui Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuan ZhangState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, P.R. China.
Bin DongState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, P.R. China.
Shan SuState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, P.R. China.
Xinxin LiState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, P.R. China.
Wenting GuoState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, P.R. China.
Zhiyi WangSchool of Materials, Sun Yat-Sen University, Shenzhen, P.R. China.ORCID https://orcid.org/0000-0002-5619-2238
Baodui WangState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, P.R. China.ORCID https://orcid.org/0000-0003-1600-6557

Funding

China Northern Rare Earth Commission Project BFXT-2023-D-0049Jinchang Science and Technology Program Project 2024NY003Lanzhou High-Level Talent Funding 127000-563225102National Natural Science Foundation of China 22221001National Natural Science Foundation of China 22377047Science and Technology Leading Talent Foundation of Gansu Province 24RCKB003
6 · The paper itself

Abstract

Photodynamic immunotherapy is constrained by the immunosuppressive tumor microenvironment (TME) that scavenges reactive oxygen species (ROS) and limits immunogenic cell death. Lanthanide-doped upconversion nanoparticles enable near-infrared-triggered singlet oxygen generation, yet their efficacy is hampered by intrinsically low upconversion luminescence efficiency and glutathione-mediated ROS quenching. Here we report a dual-locked glutathione (GSH)-activatable nanoassembly (Cy-UCMA) that integrates cascade energy transfer with self-reinforcing oxidative stress. The system employs a nitroazo-ether probe (Cy-GSH) that remains optically silent until encountering two orthogonal triggers: endogenous GSH (biochemical key) and 808 nm light (physical key). GSH triggers nucleophilic aromatic substitution to generate a NIR-absorbing antenna (Cy-SG), which sensitizes Nd

Indexed as

GlutathioneImmunotherapyNanoparticlesPhotochemotherapyAnimalsCell Line, TumorEnergy TransferHumansMiceOxidative StressReactive Oxygen SpeciesGlutathioneReactive Oxygen Speciescascade energy transferdual lockedglutathione activatablephotodynamic immunotherapy

Identifiers

PMID42528113
PMCPMC13542851

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.