Evidence map›Paper›PMID 42528093›Full record

ArticleOptometry and vision science : official publication of the American Academy of Optometry2026

Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy.

Marina Guro, Henrietta Wang, Jack Phu, Kaitlyn A Sapoznik, Hamza Shah, Maggie L Zhang, Michael Kalloniatis

Abstract readCase Reports
In one paragraph

Article in Optometry and vision science : official publication of the American Academy of Optometry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy.Optometry and vision science : official publication of the American Academy of Optometry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marina GuroUniversity of Houston College of Optometry, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-4929-740X
Henrietta WangSchool of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-6694-7622
Jack PhuUniversity of Houston College of Optometry, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-9933-6780
Kaitlyn A SapoznikUniversity of Houston College of Optometry, Houston, Texas, USA.ORCID https://orcid.org/0009-0009-7945-5828
Hamza ShahUniversity of Houston College of Optometry, Houston, Texas, USA.ORCID https://orcid.org/0009-0004-5498-0574
Maggie L ZhangUniversity of Houston College of Optometry, Houston, Texas, USA.ORCID https://orcid.org/0009-0006-8927-3946
Michael KalloniatisUniversity of Houston College of Optometry, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-5264-4639

Funding

CTSA K12 Program at Baylor College of Medicine and University of HoustonK12TR004522 · NCATS · BAYLOR COLLEGE OF MEDICINE · PI Marino A Bruce, ELENA L GRIGORENKO · 2024 to 2026
$2.6M
NCATS NIH HHS K12 TR004522NEI NIH HHS K12 TR00452
6 · The paper itself

Abstract

purposeTo highlight retinal ischemia as an important component of diabetic retinopathy (DR) pathogenesis, a significant prognostic factor, and a driver of various DR complications, including neovascularization. We aim to describe the main features of ischemic areas that can be identified through fundoscopy, color fundus photography, optical coherence tomography (OCT), and OCT angiography and provide clinicians with a step-by-step approach to identifying prognostically unfavorable markers of DR and accurately staging DR to improve management and prevent severe proliferative DR. CASE REPORTS: Cases of DR with subtle but significant retinal findings that are not readily identifiable unless a systematic multimodal imaging approach is used. We emphasize the presence of retinal ischemia in each case and show how to identify retinal vascular nonperfusion and its complications.

conclusionsAdvanced stages of DR may lack prominent fundus findings and may be easily misdiagnosed as milder DR without a comprehensive multimodal imaging diagnostic approach.

Indexed as

Diabetic RetinopathyIschemiaRetinal VesselsAgedFemaleFluorescein AngiographyFundus OculiHumansMaleMiddle AgedTomography, Optical Coherence

Identifiers

PMID42528093
PMCPMC13682613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.