Evidence map›Paper›PMID 42527799›Full record

ArticleAnnals of surgical oncology2026

Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer by Age, Race, and Tumor Subtype.

Dalliah M Black, Amy E Glasgow, Amy C Degnim, Tina J Hieken, Elizabeth B Habermann

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Dalliah M BlackDivision of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA. black.dalliah@mayo.edu.
Amy E GlasgowRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
Amy C DegnimDivision of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Tina J HiekenDivision of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Elizabeth B HabermannRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContralateral prophylactic mastectomy (CPM) is discouraged in average risk women with unilateral breast cancer (UBC) per national consensus guidelines. CPM rates among different UBC populations are unknown. Our aim was to determine CPM rates by age, race, and tumor subtype. PATIENTS AND

methodsWomen with stage I-III UBC undergoing therapeutic mastectomy were identified from SEER18 cancer registries from 2010 to 2021 to compare the no CPM group and CPM group.

resultsOf 240,613 women, 31.3% underwent CPM. Non-Hispanic white (NHW) women were more likely to undergo CPM compared with non-Hispanic black (NHB), Hispanic white, and Asian women (34.7% vs. 27.6%, 27.5%, and 20.2% respectively; p < 0.0001). CPM rates increased 8.2%, from 25.4 to 33.6%, with the greatest increase in NHB (16.7%) and the smallest in Asian women (6.3%) (p < 0.0001). On multivariable analysis (MVA), factors associated with CPM were age 18-39 years (OR 3.39), white race (OR 2.46), ER-HER2- subtype (OR 1.29), and stage I disease (OR 1.43) (all p < 0.0001). MVA considering race, age, and receptor subtype, CPM rates were highest in: NHWs age 18-49 years with triple negative breast cancer (TNBC), followed by NHWs 18-49 years with ER+ cancer, and NHBs age 18-49 years with TNBC. NHBs age 18-49 years with TNBC had the greatest increase in CPM rates (24%).

conclusionsCPM rates in women with UBC who undergo therapeutic mastectomy continue to increase. CPM was most frequent in young NHW women with TNBC. Young NHBs with TNBC had the greatest rate of increase. Further research is needed to identify factors motivating CPM, especially in average risk women with UBC.

Indexed as

Breast NeoplasmsProphylactic MastectomyTriple Negative Breast NeoplasmsUnilateral Breast NeoplasmsAdolescentAdultAgedAge FactorsAsianBlack or African AmericanFemaleFollow-Up StudiesHispanic or LatinoHumansMiddle AgedPrognosisAgeBreast cancerBreast reconstructionContralateral prophylactic mastectomyRaceTumor subtype

Identifiers

PMID42527799

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.