ReviewImmunologic research2026
Immune cells in liver transplantation: Dual roles, mechanistic insights, and targeted therapeutic strategies.
Review in Immunologic research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
Funding
Abstract
Liver transplantation is the most effective treatment for end-stage liver disease and acute liver failure; however, organ shortage and transplant rejection remain key challenges limiting its development. In recent years, the unique role of immune cells in liver transplantation has provided new insights into the mechanisms of immune rejection and tolerance. The liver's unique immune microenvironment, dominated by innate immune cells, maintains immune tolerance through complex cell-cell interactions and cytokine networks. This article systematically reviews the dynamic roles of macrophages, neutrophils, dendritic cells (DCs), natural killer (NK) cells, and regulatory T cells (Tregs) in liver transplantation, as well as emerging therapeutic strategies derived from these findings, such as Treg infusion, machine perfusion technology, and immunometabolic regulation, all of which demonstrate immense potential. Further exploration of the heterogeneity of immune cells and their dynamic regulatory networks-particularly through the use of single-cell sequencing and spatial transcriptomics to elucidate the functional plasticity and dynamic switching mechanisms of immune cell subsets-will provide crucial guidance for achieving personalized induction of immune tolerance and optimizing liver transplant outcomes, while also laying the molecular foundation for the development of more targeted immune intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.