ArticleNature2026
Mitochondrial metabolism and epigenetic crosstalk drive SASP.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Metabolism licenses the senescence secretome.Cell research · 2026Article
- The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026Review
- Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence.Cell death discovery · 2026Article
- The Sixth Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Mitochondria-Nuclear Crosstalk: Orchestrating mtDNA Maintenance.Environmental and molecular mutagenesis · 2025Review
Corrections and comments
- Update of
Authors and funding
29 authors.
Hélène MartiniDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-8789-4585
Jodie BirchMRC Laboratory of Medical Sciences (LMS), London, UK.
Francisco D M MarquesDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0001-7521-6955
Stella VictorelliDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5573-8019
Anthony B LagnadoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-9380-5179
Nicholas PiriusDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Ana Catarina FrancoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Gung LeeDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Yeaeun HanDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-1122-3691
Jennifer L RowseyRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Wazim Mohammed IsmailDivision of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1782-7296
Amelia MazzoneDivision of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6236-6962
Tianna M EspeDepartment of Oncology, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
Taro HitosugiDepartment of Oncology, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-2898-6831
Ya LiMolecular Pharmacology and Experimental Therapeutics Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.
Alexander M WashingtonDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Aaron HavasSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4291-8015
Rabi MuradSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Xue LeiSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Rebecca A PorrittSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0973-5092
Oliver D K MaddocksSchool of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-5551-9091
Jair Machado Espindola-NettoDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-0387-5059
Dominik SaulRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Sundeep KhoslaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-2936-4372
Diana JurkDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-4486-0857
Enis KostallariDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-7138-5580
Alexandre Gaspar-MaiaDivision of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-8528-5575
Peter D AdamsSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. padams@sbpdiscovery.org.ORCID http://orcid.org/0000-0002-0684-1770
João F PassosDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. passos.joao@mayo.edu.ORCID http://orcid.org/0000-0001-8765-1890
Funding
The role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2MDevelopment of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUH3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.6MInvestigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and agingR01AG082708 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.5MPathobiology of liver fibrosisR01DK136511 · NIDDK · MAYO CLINIC ROCHESTER · PI Enis Kostallari · 2023 to 2026
$1.4MDevelopment of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUG3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2021 to 2022
$1.1MNCI NIH HHS UG3 CA268103NCI NIH HHS UH3 CA268103NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG082708NIDDK NIH HHS R01 DK136511
Abstract
Senescent cells promote tissue dysfunction in part through the senescence-associated secretory phenotype (SASP)
Indexed as
Cellular SenescenceEpigenesis, GeneticMitochondriaAcetylationAcetyl Coenzyme AAgingAnimalsChromatinDNA, MitochondrialFemaleHistonesHumansImmunity, InnateInflammationMaleMiceAcetyl Coenzyme AChromatinDNA, MitochondrialHistonesMitochondrial ProteinsOrganic Anion TransportersPyruvic AcidSlc25a1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.