Evidence map›Paper›PMID 42527598›Full record

ArticleNature2026

Enzymatic glycosylation and amidation reshapes polyene bioactivity.

Saadia N Mirza, Alberto Carella, Joseph W Thompson, Deepanjan Panda, Anna R I McDonald, Matthew D Crossley, Wei Li Thong, Katherine J Robins, Sarah A Shepherd, Matthew J Cliff and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Saadia N MirzaDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College, London, UK.
Alberto CarellaManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Joseph W ThompsonDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College, London, UK.ORCID http://orcid.org/0000-0002-1789-7243
Deepanjan PandaDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College, London, UK.
Anna R I McDonaldDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College, London, UK.ORCID http://orcid.org/0009-0007-9170-8168
Matthew D CrossleyDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College, London, UK.ORCID http://orcid.org/0009-0004-1058-0157
Wei Li ThongManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Katherine J RobinsManchester Institute of Biotechnology, University of Manchester, Manchester, UK.
Sarah A ShepherdManchester Institute of Biotechnology, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7321-1234
Matthew J CliffManchester Institute of Biotechnology, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7482-0234
Clara ValeroManchester Fungal Infection Group, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-9923-4151
Andrew ThomManchester Fungal Infection Group, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0003-1230-7045
Michael BromleyManchester Fungal Infection Group, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7611-0201
Jason MicklefieldDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College, London, UK. j.micklefield@imperial.ac.uk.ORCID http://orcid.org/0000-0001-8951-4873

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal diseases are an escalating threat to human health, driven by rising antimicrobial resistance and a lack of new antifungal treatments

Indexed as

AmidesAntifungal AgentsGlycosyltransferasesPolyenesCarboxylic AcidsGlycosylationSugarsAmidesAntifungal AgentsCarboxylic AcidsGlycosyltransferasesPolyenesSugars

Identifiers

PMID42527598
PMCPMC13538060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.