Evidence map›Paper›PMID 42527560›Full record

SynthesisNature genetics2026

Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto's thyroiditis.

Melissa N Bujnis, Rosalie B T M Sterenborg, Yong Li, Bjørn Olav Åsvold, Luka Brčić, Vesna Boraska Perica, Anav Babbar, Joshua C Denny, Lars G Fritsche, Masahiro Kanai and 25 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Links between bone fractures and the gut microbiota.Nature reviews. Endocrinology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Melissa N Bujnis *Department of Human Genetics, University of Utah, Salt Lake City, UT, USA.
Rosalie B T M Sterenborg *Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4758-9185
Yong LiInstitute of Epidemiology and Prevention, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-2651-8791
Bjørn Olav ÅsvoldHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-3837-2101
Luka BrčićDepartment of Medical Biology, School of Medicine, University of Split, Split, Croatia.ORCID http://orcid.org/0000-0002-6800-8936
Vesna Boraska PericaDepartment of Medical Biology, School of Medicine, University of Split, Split, Croatia.
Anav BabbarPrecision Health Informatics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Joshua C DennyPrecision Health Informatics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3049-7332
Lars G FritscheDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2110-1690
Masahiro KanaiAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5165-4408
Ilze KonradeDepartment of Internal Medicine, Riga Stradins University, Riga, Latvia.
Graham LeeseNHS Tayside, Dundee, Scotland, UK.ORCID http://orcid.org/0000-0003-0570-5678
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-6179-1609
Andres MetspaluEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Marta R MoksnesHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0002-2690-5153
Bhramar MukherjeeDepartment of Biostatistics, Department of Chronic Disease Epidemiology and Department of Statistics and Data Science, Yale University, New Haven, CT, USA.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Colin N A PalmerDivision of Population Health & Genomics, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-6415-6560
Areti PapadopoulouWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Raitis PeculisLatvian Biomedical Research and Study Centre, Riga, Latvia.
Vita RoviteLatvian Biomedical Research and Study Centre, Riga, Latvia.
Peter J SauerPrecision Health Informatics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Enrique Soto-PedreDivision of Population Health & Genomics, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.
Sundararajan SrinivasanDivision of Population Health & Genomics, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-3387-9889
Inga SteinbrennerInstitute of Epidemiology and Prevention, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-0851-5773
Maris Teder-LavingEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5872-1850
Bin WangDepartment of Immunology, Binzhou Medical University, Yantai, China.
Antoine WeihsDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-7113-0027
Chenjie ZengPrecision Health Informatics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jin ZhouDepartment of Endocrinology and Foot & Ankle Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Biobank Japan Project
XiCheng SongDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.ORCID http://orcid.org/0000-0002-9789-1318
Lynn B JordeDepartment of Human Genetics, University of Utah, Salt Lake City, UT, USA.
Marco MediciDepartment of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands. m.medici@erasmusmc.nl.ORCID http://orcid.org/0000-0002-7271-7858
Alexander TeumerDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de.ORCID http://orcid.org/0000-0002-8309-094X

Funding

Human Genetic Variation and DiseaseR35GM118335 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JORDE, LYNN · 2016 to 2025
$5.1M
Deutsche Forschungsgemeinschaft (German Research Foundation) 530592017Deutsche Forschungsgemeinschaft (German Research Foundation) 542489987NIGMS NIH HHS R35 GM118335U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM118335
6 · The paper itself

Abstract

Autoimmune hypothyroidism (Hashimoto's thyroiditis) is common and has a strong genetic component. Here we performed multi-ancestry genome-wide association meta-analyses encompassing 48,694 Hashimoto's thyroiditis cases, using a precise case definition, and 1,044,134 controls. We identified 155 significant (P < 5 × 10

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyHashimoto DiseaseCase-Control StudiesEast Asian PeopleEuropean PeopleHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideQuantitative Trait LociThyroid GlandWhite People

Identifiers

PMID42527560
PMCPMC13447099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.