Evidence map›Paper›PMID 42527531›Full record

Articlenpj health systems2026

Orchestrated multi agents sustain accuracy under clinical-scale workloads compared to a single agent.

Eyal Klang, Mahmud Omar, Ganesh Raut, Reem Agbareia, Prem Timsina, Robert Freeman, Nicholas Gavin, Lisa Stump, Alexander W Charney, Benjamin S Glicksberg and 1 more

Abstract read
In one paragraph

Article in npj health systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A comprehensive survey of AI agents in healthcare.Journal of biomedical informatics · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Eyal Klang *The Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.
Mahmud Omar *The Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA. Mahmudomar70@gmail.com.
Ganesh RautThe Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.
Reem AgbareiaOphthalmology Department, Hadassah Medical Center, Jerusalem, Israel.
Prem TimsinaThe Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.
Robert FreemanThe Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.
Nicholas GavinThe Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.
Lisa StumpThe Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.
Alexander W CharneyThe Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.
Benjamin S GlicksbergThe Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.
Girish N NadkarniThe Windreich Department of Artificial Intelligence and Human Health, Mount Sinai Medical Center, New York, NY, USA.

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
NCATS NIH HHS UL1 TR004419NIH HHS S10 OD026880NIH HHS S10 OD030463Scientific Computing and Data at the Icahn School of Medicine at Mount Sinai UL1TR004419
6 · The paper itself

Abstract

We tested state-of-the-art LLMs under clinical-scale workloads using two designs: a single agent handling all tasks and a multi-agent orchestrator assigning each task to a dedicated worker. Across retrieval, extraction, and dosing tasks, batch sizes ranged from 5-80. Multi-agent accuracy remained high (90.6% at 5 tasks; 65.3% at 80), while single-agent accuracy collapsed (73.1% to 16.6%; p < 0.01). Multi-agent runs used up to 65-fold fewer tokens and limited latency growth. These findings show that lightweight orchestration preserves accuracy and efficiency under mixed-task clinical loads.

Identifiers

PMID42527531
PMCPMC13354228

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.