Evidence map›Paper›PMID 42527492›Full record

Reviewnpj health systems2026

Design for a digital twin in clinical patient care.

Anna-Katharina Nitschke, Carlos Brandl, Fabian Egersdörfer, Magdalena Görtz, Markus Hohenfellner, Matthias Weidemüller

Abstract readReview
In one paragraph

Review in npj health systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna-Katharina Nitschke *Physikalisches Institut, Universität Heidelberg, Heidelberg, Germany.
Carlos Brandl *Physikalisches Institut, Universität Heidelberg, Heidelberg, Germany.
Fabian EgersdörferPhysikalisches Institut, Universität Heidelberg, Heidelberg, Germany.
Magdalena GörtzJunior Clinical Cooperation Unit 'Multiparametric Methods for Early Detection of Prostate Cancer', German Cancer Research Center (DKFZ), Heidelberg, Germany.
Markus HohenfellnerDepartment of Urology, Heidelberg University Hospital, Heidelberg, Germany.
Matthias WeidemüllerPhysikalisches Institut, Universität Heidelberg, Heidelberg, Germany. weidemueller@uni-heidelberg.de.

Funding

Bundesministerium für Wirtschaft und Klimaschutz 01MT21004ABundesministerium für Wirtschaft und Klimaschutz 01MT21004FDeutsche Forschungsgemeinschaft EXC2181/1-390900948
6 · The paper itself

Abstract

Digital Twins hold great potential to personalize clinical patient care, provided the concept is translated to meet specific requirements emerging from established clinical workflows. We present a general and unspecialized Digital Twin design combining knowledge graphs and ensemble learning to reflect the entire patient's clinical journey and assist clinicians in their decision-making. Such a design is predictive, modular, evolving, informed, interpretable and explainable, thus opening broad clinical applications.

Identifiers

PMID42527492
PMCPMC13354220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.